Our Research & Other Key Publications
Catalytic Hydrogenation of Trivinyl Orthoacetate: Mechanisms Elucidated by Parahydrogen Induced Polarization
A. N. Pravdivtsev, A. Brahms, S. Kienitz, F. D. Sönnichsen, J.-B. Hövener, R. Herges, ChemPhysChem 2021, 22, 370-377.
DOI: 10.1002/cphc.202000957
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cphc.202000957
Selective excitation of hydrogen doubles the yield and improves the robustness of parahydrogen-induced polarization of low-γ nuclei
A. B. Schmidt, A. Brahms, F. Ellermann, S. Knecht, S. Berner, J. Henning, D. von Elverfeldt, R. Herges, J.-B. Hövener, A. N. Pravdivtsev, Phys. Chem. Chem. Phys. 2021, 23, 26645-26652.
DOI: 10.1039/D1CP04153C
https://pubs.rsc.org/en/content/articlelanding/2021/cp/d1cp04153c
Parahydrogen-induced polarization and spin order transfer in ethyl pyruvate at high magnetic fields
A. N. Pravdivtsev, A. Brahms, F. Ellermann, T. Stamp, R. Herges, J.-B. Hövener, Sci. Rep. 2022, 12, 19361.
DOI: 10.1038/s41598-022-22347-1
Synthesis of 13C and 2H Labeled Vinyl Pyruvate and Hyperpolarization of Pyruvate
A. Brahms, A. N. Pravdivtsev, T. Stamp, F. Ellermann, F. D. Sönnichsen, J.-B. Hövener, R. Herges, Chem. Eur. J. 2022, 28, e202201210.
DOI: 10.1002/chem.202201210
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202201210
Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation
F. Ellermann, A. Sirbu, A. Brahms, C. Assaf, R. Herges, J.-B. Höevner, A. N. Pravdivtsev, Nat. Commun. 2023, 14, 4774.
DOI: 10.1038/s41467-023-40539-9
Exceptionally Mild and High-Yielding Synthesis of Vinyl Esters of Alpha-Ketocarboxylic Acids, Including Vinyl Pyruvate, for Parahydrogen-Enhanced Metabolic Spectroscopy and Imaging
A. Brahms, A. N. Pravdivtsev, L. Thorns, F. D. Sönnichsen, J.-B. Hövener, R. Herges, J. Org. Chem. 2023, 88, 15018-15028.
DOI: 10.1021/acs.joc.3c01461
Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer
O. Mohiuddin, H. de Maissin, A. N. Pravdivtsev, A. Brahms, M. Herzog, L. Schröder, E. Y. Chekmenev, R. Herges, J.-B. Hövener, M. Zaitsev, D. von Elverfeldt, A. B. Schmidt, Commun. Chem. 2024, 7, 240.
DOI: 10.1038/s42004-024-01316-x
Parahydrogen-Induced Polarization Relayed via Proton Exchange
K. Them, F. Ellermann, A. N. Pravdivtsev, O. G. Salnikov, I. V. Skovpin, I. V. Koptyug, R. Herges, J.-B. Hövener, J. Am. Chem. Soc. 2021, 143, 13694-13700.
DOI: 10.1021/jacs.1c05254
Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions
J. P. Peters, A. Brahms, V. Janicaud, M. Anikeeva, E. Peschke, F. Ellermann, A. Ferrari, D. Hellmold, J. Held-Feindt, N.-m. Kim, J. Meiser, K. Aden, R. Herges, J.-B. Hövener, A. N. Pravdivtsev, Sci. Adv. 2023, 9, eadd3643.
DOI: 10.1126/sciadv.add3643
Analysis of chemical exchange in iridium N-heterocyclic carbene complexes using heteronuclear parahydrogen-enhanced NMR
C. D. Assaf, X. Gui, O. G. Salnikov, A. Brahms, N. V. Chukanov, I. V. Skovpin, E. Y. Chekmenev, R. Herges, S. B. Duckett, I. V. Koptyug, K. Buckenmaier, R. Körber, M. Plaumann, A. A. Auer, J.-B. Hövener, A. N. Pravdivtsev, Commun. Chem. 2024, 7, 286.
DOI: 10.1038/s42004-024-01376-z
Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization
J. P. Peters, C. Assaf, A. Brahms, K. Them, M. Gerdsen, R. Herges, J.-B. Hövener, A. N. Pravdivtsev, Sci. Adv. 2025, 11, eadx2316.
DOI: 10.1126/sciadv.adx2316
Consensus recommendations for hyperpolarized [1-13C]pyruvate MRI multi-center human studies
S. Punwani, P. E. Z. Larson, C. Laustsen, J. VanderMeulen, J. H. Ardenkjær-Larsen, A. W. Autry, J. A. Bankson, J. Bernard, R. Bok, L. B. Bertelsen, J. Che, A. P. Chen, R. Chowdhury, A. Comment, C. H. Cunningham, D. Dang, F. A. Gallagher, A. Gaunt, Y. Gong, J. W. Gordon, A. Grimmer, J. Grist, E. S. S. Hansen, M. H. Lerche, R. L. Hesketh, J.-B. Hoevener, C.-Y. Hsieh, K. R. Keshari, S. Kozerke, T. Lanz, D. Mayer, M. McLean, J. M. Park, J. Slater, D. Tyler, J.-L. Vanderheyden, C. von Morze, F. Zaccagna, V. Zaha, D. Xu, D. Vigneron, Magn. Reson. Med. 2025, 94, 1386-1400.
DOI: 10.1002/mrm.30570
Parahydrogen-Based Hyperpolarization for Biomedicine
J.-B. Hövener, A. N. Pravdivtsev, B. Kidd, C. R. Bowers, S. Glöggler, K. V. Kovtunov, M. Plaumann, R. Katz-Brull, K. Buckenmaier, A. Jerschow, F. Reineri, T. Theis, R. V. Shchepin, S. Wagner, P. Bhattacharya, N. M. Zacharias, E. Y. Chekmenev, Angew. Chem. Int. Ed. 2018, 57, 11140-11162.
DOI: 10.1002/anie.201711842
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201711842
ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate
F. Reineri, T. Boi, S. Aime, Nat. Commun. 2015, 6, 5858.
DOI: 10.1038/ncomms6858
Heteronuclear Parahydrogen-Induced Hyperpolarization via Side Arm Hydrogenation
O. G. Salnikov, N. V. Chukanov, A. N. Pravdivtsev, D. B. Burueva, S. V. Sviyazov, K. Them, J.-B. Hövener, I. V. Koptyug, ChemPhysChem 2025, 26, e202401119.
DOI: 10.1002/cphc.202401119
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cphc.202401119